How should you take CABOMETYX?

CABOMETYX is a tablet you take once a day.

CABOMETYX Dosing Information; Instructions

Take at the same time every day, but...

CABOMETYX Dosing Information; Eating
CABOMETYX Dosing Information; Grapefruit
Do not drink grapefruit juice, eat grapefruit or supplements that contain grapefruit during treatment with CABOMETYX.

What should you do if you forget to take CABOMETYX?

If you forget to take your CABOMETYX and you should be taking your next dose in:

 

  • Do not try to make up the missed dose
  • Take the next dose when you usually take it

 

  • Take the missed dose as soon as possible
  • Take the next dose when you usually take it
CABOMETYX Side Effects Tips; call your oncology doctor

Call your healthcare provider right away if you take too much CABOMETYX.

Will your CABOMETYX dose change?

Your oncology doctor or nurse may adjust your dose to help manage certain side effects. They may:

CABOMETYX dose adjustment; pause
PAUSE your CABOMETYX for a little while
or
CABOMETYX dose adjustment; lower
LOWER your CABOMETYX dose

Each person who takes CABOMETYX will respond differently. You and your oncology doctor will figure out what dose is right for you based on how your body responds to CABOMETYX.

In the clinical trials, many patients paused their treatment or had their dose lowered to manage certain side effects. Most people in the clinical trials had at least one dose reduction.

There are 3 different doses for CABOMETYX
60 mg CABOMETYX dose60 mg
40 mg CABOMETYX dose40 mg
20 mg CABOMETYX dose20 mg

Tablets are not actual size

Be sure to take your medication as recommended by your oncology doctor.

Tips to help you remember to take CABOMETYX

It is important to take your medication as directed by your oncology doctor. Here are some tips you may find helpful.

CABOMETYX Dosing Tip; Calendar
Keep a calendar in an easy-to-see place and mark it each time you take your medication
CABOMETYX Dosing Tip; pill box
Use a weekly pillbox
CABOMETYX Dosing Tip; Phone reminder
Set an alarm on your clock, computer, or phone, and take your medicine when the alarm alerts you
CABOMETYX Dosing Tip; routine
Take your CABOMETYX right before or after a daily routine like brushing your teeth or feeding your pet
CABOMETYX Dosing Tip; in sight
Keep your CABOMETYX in an easy-to-see spot so they act as a visual reminder (Remember to keep your medication out of reach of children)
CABOMETYX Dosing Tip; call reminder
Ask a family member or friend to call or stop by to help remind you
CABOMETYX Dosing Tip; ask your doctor
Talk with your doctor, nurse or pharmacist. They may be able to offer suggestions to help
 

INDICATION AND IMPORTANT SAFETY INFORMATION


What is CABOMETYX?

CABOMETYX is a prescription medicine used to treat people with advanced kidney cancer (renal cell carcinoma).

It is not known if CABOMETYX is safe and effective in children.

What are the possible side effects of CABOMETYX?


CABOMETYX may cause serious side effects, including:

  • Severe bleeding (hemorrhage). Tell your healthcare provider right away if you get any signs of bleeding during treatment with CABOMETYX, including:
    • coughing up blood or blood clots
    • vomiting blood or if your vomit looks like coffee-grounds
    • red or black (looks like tar) stools
    • menstrual bleeding that is heavier than normal
    • any unusual or heavy bleeding
  • A tear in your stomach or intestinal wall (perforation) or an abnormal connection between 2 parts of your body (fistula). Tell your healthcare provider right away if you get tenderness or pain in your stomach-area (abdomen).
  • Blood clots, stroke, heart attack, and chest pain. Get emergency help right away if you get:
    • swelling or pain in your arms or legs
    • shortness of breath
    • feel lightheaded or faint
    • sweating more than usual
    • numbness or weakness of your face, arm or leg, especially on one side of your body
    • sudden confusion, trouble speaking or understanding
    • sudden trouble seeing in one or both eyes
    • sudden trouble walking
    • dizziness, loss of balance or coordination
    • a sudden severe headache
  • High blood pressure (hypertension). Hypertension is common with CABOMETYX and sometimes can be severe. Your healthcare provider will check your blood pressure before starting CABOMETYX and during treatment with CABOMETYX. If needed, your healthcare provider may prescribe medicine to treat your high blood pressure.
  • Diarrhea. Diarrhea is common with CABOMETYX and can be severe. If needed, your healthcare provider may prescribe medicine to treat your diarrhea. Tell your healthcare provider right away, if you have frequent loose, watery bowel movements.
  • A skin problem called hand-foot skin reaction. Hand-foot skin reactions are common and can be severe. Tell your healthcare provider right away if you have rashes, redness, pain, swelling, or blisters on the palms of your hands or soles of your feet.
  • Reversible Posterior Leukoencephalopathy Syndrome (RPLS). A condition called reversible posterior leukoencephalopathy syndrome can happen during treatment with CABOMETYX. Tell your healthcare provider right away if you have headaches, seizures, confusion, changes in vision, or problems thinking.

Your healthcare provider may change your dose, temporarily stop, or permanently stop treatment with CABOMETYX if you have certain side effects.

The most common side effects of CABOMETYX are:

  • tiredness
  • nausea
  • decreased appetite
  • weight loss
  • vomiting
  • altered sense of taste
  • inflamed and sore mouth

Tell your healthcare provider if you have any side effect that bothers you or that does not go away.

These are not all the possible side effects of CABOMETYX. For more information, ask your healthcare provider or pharmacist. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Before you take CABOMETYX, tell your healthcare provider about all of your medical conditions, including if you:

  • have any unusual bleeding
  • have high blood pressure
  • Plan to have any surgery, including dental surgery. You should stop treatment with CABOMETYX at least 28 days before any scheduled surgery.
  • Have liver problems
  • Are pregnant, or plan to become pregnant. CABOMETYX can harm your unborn baby. If you are able to become pregnant, you should use effective birth control during treatment and for 4 months after your final dose of CABOMETYX. Talk to your healthcare provider about birth control methods that may be right for you. If you become pregnant or think you are pregnant, tell your healthcare provider right away.
  • Are breastfeeding or plan to breastfeed. It is not known if CABOMETYX passes into your breast milk. Do not breastfeed during treatment and for 4 months after your final dose of CABOMETYX.

Tell your healthcare provider about all the medicines you take, including prescription or over-the-counter medicines, vitamins, and herbal supplements. CABOMETYX and certain other medicines may affect each other causing side effects.

What should I avoid while taking CABOMETYX?

Do not drink grapefruit juice, eat grapefruit or supplements that contain grapefruit during treatment with CABOMETYX.

Please see the Patient Information in the accompanying full Prescribing Information.