How do I take CABOMETYX?

CABOMETYX is a tablet you take once a day.

HOW?

WHEN? At the same time every day, but...

Do not drink grapefruit juice, eat grapefruit or supplements that contain grapefruit during treatment with CABOMETYX.

What do I do if I forget to take CABOMETYX?

If you forget to take your CABOMETYX and you should be taking your next dose in:

LESS THAN 12 HOURS

  • Do not try to make up the missed dose
  • Take the next dose when you usually take it

12 OR MORE HOURS

  • Take the missed dose as soon as possible
  • Take the next dose when you usually take it

Call your healthcare provider right away if you take too much CABOMETYX.

Will my CABOMETYX dose change?

Your oncology doctor or nurse may manage certain side effects by adjusting your dose. They may:

PAUSE your CABOMETYX for a little while
or
LOWER your CABOMETYX dose

Each person who takes CABOMETYX will respond differently. You and your oncologist will figure out what dose is right for you based on how your body responds to CABOMETYX.

In the clinical trials, many patients paused their treatment or had their dose lowered to manage certain side effects. Most people in the clinical trials had at least one dose reduction.

There are 3 different doses for CABOMETYX
60 mg60mg
40 mg40mg
20 mg20mg

Tablets are not actual size

Be sure to take your medication as recommended by your oncology doctor.

Ask your oncology doctor or nurse about anything you don’t understand. This will help you learn more about your treatment, your treatment goals, and what you can do to help with your care.

Tips to help you remember to take CABOMETYX

It is important to take your medication as directed by your oncology doctor. Here are some tips you may find helpful.

Keep a calendar in an easy to see place and mark it each time you take your medication
Use a weekly pillbox
Set the alarm on your clock, computer, or phone
Take your CABOMETYX right before or after a daily routine like brushing your teeth or feeding your pet
Keep your CABOMETYX in easy-to-see spots so they act as a visual reminder (Remember to keep your medication out of reach of children.)
Ask a family member or friend to call or stop by to help remind you
Talk with your doctor, nurse or pharmacist. They may be able to offer suggestions to help
 

INDICATION AND IMPORTANT SAFETY INFORMATION


What is CABOMETYX?

CABOMETYX is a prescription medicine used to treat people with advanced kidney cancer (renal cell carcinoma).

It is not known if CABOMETYX is safe and effective in children.

What are the possible side effects of CABOMETYX?


CABOMETYX may cause serious side effects, including:

  • Severe bleeding (hemorrhage). Tell your healthcare provider right away if you get any signs of bleeding during treatment with CABOMETYX, including:
    • coughing up blood or blood clots
    • vomiting blood or if your vomit looks like coffee-grounds
    • red or black (looks like tar) stools
    • menstrual bleeding that is heavier than normal
    • any unusual or heavy bleeding
  • A tear in your stomach or intestinal wall (perforation) or an abnormal connection between 2 parts of your body (fistula). Tell your healthcare provider right away if you get tenderness or pain in your stomach-area (abdomen).
  • Blood clots, stroke, heart attack, and chest pain. Get emergency help right away if you get:
    • swelling or pain in your arms or legs
    • shortness of breath
    • feel lightheaded or faint
    • sweating more than usual
    • numbness or weakness of your face, arm or leg, especially on one side of your body
    • sudden confusion, trouble speaking or understanding
    • sudden trouble seeing in one or both eyes
    • sudden trouble walking
    • dizziness, loss of balance or coordination
    • a sudden severe headache
  • High blood pressure (hypertension). Hypertension is common with CABOMETYX and sometimes can be severe. Your healthcare provider will check your blood pressure before starting CABOMETYX and during treatment with CABOMETYX. If needed, your healthcare provider may prescribe medicine to treat your high blood pressure.
  • Diarrhea. Diarrhea is common with CABOMETYX and can be severe. If needed, your healthcare provider may prescribe medicine to treat your diarrhea. Tell your healthcare provider right away, if you have frequent loose, watery bowel movements.
  • A skin problem called hand-foot skin reaction. Hand-foot skin reactions are common and can be severe. Tell your healthcare provider right away if you have rashes, redness, pain, swelling, or blisters on the palms of your hands or soles of your feet.
  • Reversible Posterior Leukoencephalopathy Syndrome (RPLS). A condition called reversible posterior leukoencephalopathy syndrome can happen during treatment with CABOMETYX. Tell your healthcare provider right away if you have headaches, seizures, confusion, changes in vision, or problems thinking.

Your healthcare provider may change your dose, temporarily stop, or permanently stop treatment with CABOMETYX if you have certain side effects.

The most common side effects of CABOMETYX are:

  • tiredness
  • nausea
  • decreased appetite
  • weight loss
  • vomiting
  • altered sense of taste
  • inflamed and sore mouth

Tell your healthcare provider if you have any side effect that bothers you or that does not go away.

These are not all the possible side effects of CABOMETYX. For more information, ask your healthcare provider or pharmacist. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Before you take CABOMETYX, tell your healthcare provider about all of your medical conditions, including if you:

  • have any unusual bleeding
  • have high blood pressure
  • Plan to have any surgery, including dental surgery. You should stop treatment with CABOMETYX at least 28 days before any scheduled surgery.
  • Have liver problems
  • Are pregnant, or plan to become pregnant. CABOMETYX can harm your unborn baby. If you are able to become pregnant, you should use effective birth control during treatment and for 4 months after your final dose of CABOMETYX. Talk to your healthcare provider about birth control methods that may be right for you. If you become pregnant or think you are pregnant, tell your healthcare provider right away.
  • Are breastfeeding or plan to breastfeed. It is not known if CABOMETYX passes into your breast milk. Do not breastfeed during treatment and for 4 months after your final dose of CABOMETYX.

Tell your healthcare provider about all the medicines you take, including prescription or over-the-counter medicines, vitamins, and herbal supplements. CABOMETYX and certain other medicines may affect each other causing side effects.

What should I avoid while taking CABOMETYX?

Do not drink grapefruit juice, eat grapefruit or supplements that contain grapefruit during treatment with CABOMETYX.

Please see the Patient Information in the accompanying full Prescribing Information.