Frequently asked questions

  • Is there anything I should tell my healthcare professional before I take CABOMETYX?

    Yes. Make sure to let your oncology doctor or nurse know if you:

    • Have any unusual bleeding
    • Have high blood pressure
    • Plan to have any surgery, including dental surgery. You should stop treatment with CABOMETYX at least 28 days before any scheduled surgery
    • Have liver problems
    • Are pregnant, or plan to become pregnant. CABOMETYX can harm your unborn baby. If you are able to become pregnant, you should use effective birth control during treatment and for 4 months after your final dose of CABOMETYX. Talk to your healthcare provider about birth control methods that may be right for you. If you become pregnant or think you are pregnant, tell your healthcare provider right away
    • Are breastfeeding or plan to breastfeed. It is not known if CABOMETYX passes into your breast milk. Do not breastfeed during treatment and for 4 months after your final dose of CABOMETYX

    Tell your healthcare provider about all the medicines you take, including prescription or over-the-counter medicines, vitamins, and herbal supplements. CABOMETYX and certain other medicines may affect each other, causing side effects.

  • What should I do if I forget to take CABOMETYX?

    If you forget to take your CABOMETYX and you should be taking your next dose in:

    LESS THAN 12 HOURS

    • Do not try to make up the missed dose
    • Take the next dose when you usually take it

    12 OR MORE HOURS

    • Take the missed dose as soon as possible
    • Take the next dose when you usually take it

     

    Call your healthcare provider right away if you take too much CABOMETYX. Looking for more information about taking CABOMETYX?

  • What are common side effects of CABOMETYX?

    The most common side effects of CABOMETYX are:

    • Tiredness
    • Nausea
    • Decreased appetite
    • Weight loss
    • Vomiting
    • Altered sense of taste
    • Inflamed and sore mouth

    Tell your healthcare provider if you have any side effect that bothers you or does not go away.
    Looking for more information about potential side effects?

  • Can side effects be managed?

    Certain side effects can be managed.

    Your oncology doctor may change your dose to help manage side effects. A complete overview of how your dose may change can be found here.

    There are also tips to help manage certain side effects. A list of these side effects and tips can be found here.

  • What should I avoid while taking CABOMETYX?

    Do not drink grapefruit juice, eat grapefruit or supplements that contain grapefruit during treatment with CABOMETYX.

    Tell your healthcare provider about all the medicines you take, including prescription or over-the-counter medicines, vitamins, and herbal supplements. CABOMETYX and certain other medicines may affect each other, causing side effects.

    Looking for more information about taking CABOMETYX?

  • What if I need help getting and paying for CABOMETYX?

    Exelixis® Access Services (EASE) is your resource for questions and needs related to coverage, financial assistance, and treatment support for CABOMETYX.

    Looking for more information about financial support?

Glossary of terms

Advanced: When cancer has spread from the original site—in this case, your kidney—and moved to other parts of the body.

Clinical trial: Research that is designed to test new medical approaches, such as new medicines, and how they work in people.

Intravenously: Giving a drug through a needle or tube placed into the vein.

Molecule: The joining of two or more atoms (tiny particles). Atoms from the same element can join together, or atoms from 2 different elements can join together. For example, H2O, or water, is a molecule made by the joining of 2 hydrogen atoms and an oxygen atom.

Oncologist: A physician who diagnoses and treats cancer. This person is the main contact point for any CABOMETYX-related questions. He or she may also coordinate treatment given by other specialists.

Tumor: An abnormal mass of cells that increases in size because these cells grow more quickly than they should and don’t die when they should. A tumor can be either cancerous or benign (not cancer).

 

INDICATION AND IMPORTANT SAFETY INFORMATION


What is CABOMETYX?

CABOMETYX is a prescription medicine used to treat people with advanced kidney cancer (renal cell carcinoma).

It is not known if CABOMETYX is safe and effective in children.

What are the possible side effects of CABOMETYX?


CABOMETYX may cause serious side effects, including:

  • Severe bleeding (hemorrhage). Tell your healthcare provider right away if you get any signs of bleeding during treatment with CABOMETYX, including:
    • coughing up blood or blood clots
    • vomiting blood or if your vomit looks like coffee-grounds
    • red or black (looks like tar) stools
    • menstrual bleeding that is heavier than normal
    • any unusual or heavy bleeding
  • A tear in your stomach or intestinal wall (perforation) or an abnormal connection between 2 parts of your body (fistula). Tell your healthcare provider right away if you get tenderness or pain in your stomach-area (abdomen).
  • Blood clots, stroke, heart attack, and chest pain. Get emergency help right away if you get:
    • swelling or pain in your arms or legs
    • shortness of breath
    • feel lightheaded or faint
    • sweating more than usual
    • numbness or weakness of your face, arm or leg, especially on one side of your body
    • sudden confusion, trouble speaking or understanding
    • sudden trouble seeing in one or both eyes
    • sudden trouble walking
    • dizziness, loss of balance or coordination
    • a sudden severe headache
  • High blood pressure (hypertension). Hypertension is common with CABOMETYX and sometimes can be severe. Your healthcare provider will check your blood pressure before starting CABOMETYX and during treatment with CABOMETYX. If needed, your healthcare provider may prescribe medicine to treat your high blood pressure.
  • Diarrhea. Diarrhea is common with CABOMETYX and can be severe. If needed, your healthcare provider may prescribe medicine to treat your diarrhea. Tell your healthcare provider right away, if you have frequent loose, watery bowel movements.
  • A skin problem called hand-foot skin reaction. Hand-foot skin reactions are common and can be severe. Tell your healthcare provider right away if you have rashes, redness, pain, swelling, or blisters on the palms of your hands or soles of your feet.
  • Reversible Posterior Leukoencephalopathy Syndrome (RPLS). A condition called reversible posterior leukoencephalopathy syndrome can happen during treatment with CABOMETYX. Tell your healthcare provider right away if you have headaches, seizures, confusion, changes in vision, or problems thinking.

Your healthcare provider may change your dose, temporarily stop, or permanently stop treatment with CABOMETYX if you have certain side effects.

The most common side effects of CABOMETYX are:

  • tiredness
  • nausea
  • decreased appetite
  • weight loss
  • vomiting
  • altered sense of taste
  • inflamed and sore mouth

Tell your healthcare provider if you have any side effect that bothers you or that does not go away.

These are not all the possible side effects of CABOMETYX. For more information, ask your healthcare provider or pharmacist. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Before you take CABOMETYX, tell your healthcare provider about all of your medical conditions, including if you:

  • have any unusual bleeding
  • have high blood pressure
  • Plan to have any surgery, including dental surgery. You should stop treatment with CABOMETYX at least 28 days before any scheduled surgery.
  • Have liver problems
  • Are pregnant, or plan to become pregnant. CABOMETYX can harm your unborn baby. If you are able to become pregnant, you should use effective birth control during treatment and for 4 months after your final dose of CABOMETYX. Talk to your healthcare provider about birth control methods that may be right for you. If you become pregnant or think you are pregnant, tell your healthcare provider right away.
  • Are breastfeeding or plan to breastfeed. It is not known if CABOMETYX passes into your breast milk. Do not breastfeed during treatment and for 4 months after your final dose of CABOMETYX.

Tell your healthcare provider about all the medicines you take, including prescription or over-the-counter medicines, vitamins, and herbal supplements. CABOMETYX and certain other medicines may affect each other causing side effects.

What should I avoid while taking CABOMETYX?

Do not drink grapefruit juice, eat grapefruit or supplements that contain grapefruit during treatment with CABOMETYX.

Please see the Patient Information in the accompanying full Prescribing Information.